Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma.

Comparisons of trisulfapyrimidines and a placebo were made in treating mild, uncomplicated chronic trachoma in groups of American Indians in 2 boarding schools. Therapy was evaluated in terms of clinical response and prevalence of fluorescent antibody staining TRIC agent in conjunctival smears. Blood sulfonamide levels taken once in the 3-week course of therapy were 7-8 mg/100 ml on the average. Ten weeks after the end of therapy, a significant improvement in clinical trachoma was found by ophthalmologist A in drug-treated cases at the first school. In the second school, ophthalmologist B found no difference between placebo and drug-treated groups.